Nature Search

US takes the offensive on animal research

G. Christopher Anderson
News05 Apr 1990
Nature

Volume: 344, P: 477
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Tissue fibrosis is a major contributor to mortality in the developed world. Here, the authors identify a genetic variant in the intronic region of interferon-λ4 that is a strong predictor of hepatic inflammation and fibrosis, independent of liver disease aetiology

Mohammed Eslam
Ahmed M. Hashem
Rosanna Santaro
ResearchOpen Access05 Mar 2015
Nature Communications

Volume: 6, P: 1-10
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression.

Khaled Thabet
Anastasia Asimakopoulos
Rosanna Santaro
ResearchOpen Access15 Sept 2016
Nature Communications

Volume: 7, P: 1-8
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

Jacob George and colleagues examine whether the association of the IFNL3–IFNL4 region with hepatic inflammation and fibrosis is mediated by IFN-λ3 or IFN-λ4. They find greater hepatic inflammation, fibrosis progression rate and hepatic infiltration of immune cells in individuals with the risk haplotype that produces IFN-λ3 but not IFN-λ4.

Mohammed Eslam
Duncan McLeod
Rosanna Santoro
Research10 Apr 2017
Nature Genetics

Volume: 49, P: 795-800
An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate

Microbial enzymes are capable of degrading certain synthetic polymers, with most polyethylene terephthalate (PET) degrading enzymes known to derive from bacteria or fungi. Here, the authors describe an archaeal originating feruloyl-esterase PET46 enzyme with a flexible lid domain and PET degradation capability.

Pablo Perez-Garcia
Jennifer Chow
Wolfgang R. Streit
ResearchOpen Access11 Sept 2023
Communications Chemistry

Volume: 6, P: 1-13
Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior

Holly K. Harris
Tojo Nakayama
Timothy W. Yu
Research03 Mar 2021
Genetics in Medicine

Volume: 23, P: 1028-1040
Combining computer vision and deep learning to enable ultra-scale aerial phenotyping and precision agriculture: A case study of lettuce production

Alan Bauer
Aaron George Bostrom
Ji Zhou
ResearchOpen Access01 Jun 2019
Horticulture Research

Volume: 6, P: 1-12
Distinguishing chronic low back pain in young adults with mild to moderate pain and disability using trunk compliance

Alexander Stamenkovic
Brian C. Clark
James S. Thomas
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-10

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US takes the offensive on animal research

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate

Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior

Combining computer vision and deep learning to enable ultra-scale aerial phenotyping and precision agriculture: A case study of lettuce production

Distinguishing chronic low back pain in young adults with mild to moderate pain and disability using trunk compliance

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