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Showing 1–6 of 6 results
Advanced filters: Author: Christopher D Vanderwal Clear advanced filters

  • A strong acid catalyst and a small change to one reactant have transformed a 37-year-old 'curiosity' into a useful chemical reaction that has great potential in organic synthesis.

    • Sarah E. Steinhardt
    • Christopher D. Vanderwal
    News & Views
    Nature Chemistry
    Volume: 2, P: 254-256

  • Several natural and unnatural lissoclimide cytotoxins have been prepared via semi-synthesis and total synthesis. An X-ray co-crystal structure of chlorolissoclimide with the ribosome and evaluation of cytotoxicity and translation inhibition of new compounds in the series improves our understanding of the molecular basis for cytotoxicity.

    • Zef A. Könst
    • Anne R. Szklarski
    • Christopher D. Vanderwal
    Research
    Nature Chemistry
    Volume: 9, P: 1140-1149

  • Previously conspicuous by its absence, a syn-selective dichlorination reaction of alkenes has now been reported, bringing together decades-old stoichiometric chemistry in a useful catalytic process.

    • Brian R. Atwood
    • Christopher D. Vanderwal
    News & Views
    Nature Chemistry
    Volume: 7, P: 99-100

  • The development of synthetic routes to unusual and complex molecules frequently leads to surprising lessons about chemical reactivity. The first synthesis of a marine toxin provides just such a lesson.

    • D. Karl Bedke
    • Christopher D. Vanderwal
    News & Views
    Nature
    Volume: 457, P: 548-549