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Aminoacylation of RNA minihelices with alanine

Christopher Francklyn
Paul Schimmel
Research02 Feb 1989
Nature

Volume: 337, P: 478-481
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Borrelidin is an antibiotic with antimicrobial, antifungal, antimalarial and immunosuppressive activity that targets threonyl-tRNA synthetase. Here the authors show that borrelidin functions by preventing binding of all three ThrRS substrates and inducing a distinct, non-productive, conformation of the enzyme.

Pengfei Fang
Xue Yu
Min Guo
ResearchOpen Access31 Mar 2015
Nature Communications

Volume: 6, P: 1-11
Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase

Rajan Sankaranarayanan
Anne-Catherine Dock-Bregeon
Dino Moras
Research01 Jun 2000
Nature Structural Biology

Volume: 7, P: 461-465
Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Tamara F. Williams
Adam C. Mirando
Karen M. Lounsbury
ResearchOpen Access21 Feb 2013
Scientific Reports

Volume: 3, P: 1-7
Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

tRNAs are linked with their cognate amino acid by aminoacyl tRNA synthetases (ARS). Here, the authors report a developmental encephalopathy associated with biallelic VARS variants (valyl-tRNA synthetase) that lead to loss of function, as determined by several in vitro assays and a vars knockout zebrafish model.

Aleksandra Siekierska
Hannah Stamberger
Peter De Jonghe
ResearchOpen Access12 Feb 2019
Nature Communications

Volume: 10, P: 1-15
Charging two for the price of one

A structure of the complex of tRNA^Glu and class I glutamyl-tRNA synthetase from Thermus thermophilus provides new details of tRNA recognition, and an accompanying mutational study provides a model for how a discriminating enzyme could have evolved from a less discriminating predecessor.

Christopher S. Francklyn
News & Views01 Mar 2001
Nature Structural Biology

Volume: 8, P: 189-191
Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Adam C. Mirando
Pengfei Fang
Christopher S. Francklyn
ResearchOpen Access14 Aug 2015
Scientific Reports

Volume: 5, P: 1-17

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Aminoacylation of RNA minihelices with alanine

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

Charging two for the price of one

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

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