In the second of three papers on the genetics of schizophrenia, a large genome-wide association study looking at common genetic variants underlying the risk of schizophrenia implicates the major histocompatibility complex — and thus, immunity — and provides molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia. The latter involves thousands of common alleles of very small effect that also contribute to the risk of bipolar disorder.
- Shaun M. Purcell
- Naomi R. Wray
- Pamela Sklar
