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Showing 1–4 of 4 results
Advanced filters: Author: Christopher J Gillson Clear advanced filters

  • Ken Ong and colleagues report a genome-wide association study for age at menarche. They find LIN28B associated with age at menarche, as well as several traits related to onset of puberty in both females and males.

    • Ken K Ong
    • Cathy E Elks
    • Nicholas J Wareham
    Research
    Nature Genetics
    Volume: 41, P: 729-733

  • Joel Hirschhorn and colleagues report results of a large-scale genome-wide association and replication study for obesity-related traits. The newly discovered loci are enriched for genes expressed in the central nervous system, and may thus contribute to weight gain by modulating food intake. Similar results are reported in a related study by Gudmar Thorleifsson and colleagues.

    • Cristen J Willer
    • Elizabeth K Speliotes
    • Joel N Hirschhorn
    Research
    Nature Genetics
    Volume: 41, P: 25-34

  • Splicing factors such as BUD31 are identified in a synthetic-lethal screen with cells overexpressing the transcription factor MYC; oncogenic MYC leads to an increase in pre-mRNA synthesis, and spliceosome inhibition impairs the growth and tumorigenicity of MYC-dependent breast cancers, suggesting that spliceosome components may be potential therapeutic targets for MYC-driven cancers.

    • Tiffany Y.-T. Hsu
    • Lukas M. Simon
    • Thomas F. Westbrook
    Research
    Nature
    Volume: 525, P: 384-388