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Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs

Here, the authors discover over 15,000 eQTLs in human kidney samples by integrating single-nucleus open chromatin data, resulting in high resolution eQTLs, increased enrichment of GWAS heritability and colocalization, followed by downstream validation.

Seong Kyu Han
Michelle T. McNulty
Matthew G. Sampson
ResearchOpen Access19 Apr 2023
Nature Communications

Volume: 14, P: 1-16

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Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs

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