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Showing 1–4 of 4 results
Advanced filters: Author: Christopher J. Podracky Clear advanced filters

  • A custom adenine base editor can edit the variant of the β-globin gene that causes sickle cell disease into a non-pathogenic variant in human and mouse cells, and transplantation of the edited cells rescues sickle cell disease in mice.

    • Gregory A. Newby
    • Jonathan S. Yen
    • David R. Liu
    Research
    Nature
    Volume: 595, P: 295-302

  • Laboratory evolution of the bacterial transpeptidase sortase A coupled with yeast display selection enables a change of the enzyme’s substrate preference to recognize and covalently label endogenous amyloid-β protein, impeding the protein’s ability to aggregate.

    • Christopher J. Podracky
    • Chihui An
    • David R. Liu
    Research
    Nature Chemical Biology
    Volume: 17, P: 317-325

  • This historical Perspective on continuous directed evolution focuses on laboratory approaches that enable greater understanding of evolving molecular populations and offer investigators tools to guide the emergence of new biomolecular systems.

    • Mary S. Morrison
    • Christopher J. Podracky
    • David R. Liu
    Reviews
    Nature Chemical Biology
    Volume: 16, P: 610-619