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Showing 1–5 of 5 results
Advanced filters: Author: Christopher M. Hoel Clear advanced filters

  • Oceans provide essential ecosystem services to human society, yet the climate impacts on blue capital have long been ignored. Incorporating the latest works on ocean science and economics, researchers show that accounting for the potential damage would almost double the social cost of carbon estimation.

    • Bernardo A. Bastien-Olvera
    • Octavio Aburto-Oropeza
    • Katharine Ricke
    Research
    Nature Climate Change
    P: 1-8

  • Tweety Homologs (TTYHs) are highly conserved membrane proteins, whose functions remain poorly understood. Here, the authors present the cryo-EM structures of murine TTYH2 and TTYH3 that form cis-dimers in the presence of Ca2+, whereas in the absence of Ca2+ TTYH2 adopts monomeric and trans-dimeric structures. The presented structures lack ion conducting pathways, which is consistent with results from electrophysiology measurements.

    • Baobin Li
    • Christopher M. Hoel
    • Stephen G. Brohawn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • A cryo-EM structure of SARS-CoV-2 ORF3a reveals a new fold conserved in coronaviruses, and functional experiments show ion channel activity that may be important for viral infectivity.

    • David M. Kern
    • Ben Sorum
    • Stephen G. Brohawn
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 573-582

  • In some systems, a single protein comprising reverse transcriptase (RT), integrase and maturase enables concerted sequence integration and crRNA production. Here, analyses including the structure of a Cas6-RT-Cas1—Cas2 complex suggest coordination between all three active sites and capacity to acquire CRISPR sequences from RNA and DNA substrates.

    • Joy Y. Wang
    • Christopher M. Hoel
    • Jennifer A. Doudna
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14