Nature Search

White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter

The white pupae (wp) phenotype has been used for decades to selectively remove females of tephritid species in genetic sexing, but the determining gene is unknown. Here, the authors show that wp phenotype is produced by parallel mutations in a Major Facilitator Superfamily domain containing gene across multiple species.

Christopher M. Ward
Roswitha A. Aumann
Marc F. Schetelig
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Publisher Correction: Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

Priscilla K. Brastianos
Eudocia Quant Lee
Ryan J. Sullivan
Amendments and Corrections18 Jun 2020
Nature Medicine

Volume: 26, P: 1309
A multi-omic atlas of human embryonic skeletal development

A multiomic atlas of human embryonic joint and cranium development enables detailed analysis of bone and cartilage maturation.

Ken To
Lijiang Fei
Sarah A. Teichmann
ResearchOpen Access20 Nov 2024
Nature

Volume: 635, P: 657-667
Single-cell integration reveals metaplasia in inflammatory gut diseases

The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal architecture and promote further inflammation.

Amanda J. Oliver
Ni Huang
Sarah A. Teichmann
ResearchOpen Access20 Nov 2024
Nature

Volume: 635, P: 699-707
Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion progression.

Jennifer E. Beane
Sarah A. Mazzilli
Avrum E. Spira
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-13
Five million years of Antarctic Circumpolar Current strength variability

The strength of the Antarctic Circumpolar Current, as traced in sediment cores from the Pacific Southern Ocean, shows no linear long-term trend over the past 5.3 Myr; instead, the strongest flow occurs consistently in warmer-than-present intervals.

Frank Lamy
Gisela Winckler
Xiangyu Zhao
ResearchOpen Access27 Mar 2024
Nature

Volume: 627, P: 789-796
West Antarctic ice volume variability paced by obliquity until 400,000 years ago

The advance and retreat of the West Antarctic Ice Sheet were primarily paced by 41,000-year-long obliquity cycles, not longer eccentricity cycles, until 400,000 years ago, according to sedimentological and palaeomagnetic records from the Ross Embayment.

Christian Ohneiser
Christina L. Hulbe
Rachel A. Worthington
Research05 Dec 2022
Nature Geoscience

Volume: 16, P: 44-49
Variability of El Niño/Southern Oscillation activity at millennial timescales during the Holocene epoch

Christopher M. Moy
Geoffrey O. Seltzer
David M. Anderson
Research14 Nov 2002
Nature

Volume: 420, P: 162-165
Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

The relationship between genomic alteration and immune context in non-small cell lung cancer (NSCLC) is complex. Here, the authors analyse the molecular and immunological landscape of 245 Chinese patients with NSCLC and find low immune infiltration correlates with genomic alterations.

Xu-Chao Zhang
Jun Wang
Yi-Long Wu
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Artificial intelligence system reduces false-positive findings in the interpretation of breast ultrasound exams

Ultrasound is an important imaging modality for the detection and characterization of breast cancer, but it has been noted to have high false-positive rates. Here, the authors present an artificial intelligence system that achieves radiologist-level accuracy in identifying breast cancer in ultrasound imaging.

Yiqiu Shen
Farah E. Shamout
Krzysztof J. Geras
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

In a phase 2 clinical trial cohort of patients with leptomeningeal disease, anti-PD-1 monotherapy was safe and associated with a 3-month overall survival of 60%.

Priscilla K. Brastianos
Eudocia Quant Lee
Ryan J. Sullivan
Research02 Jun 2020
Nature Medicine

Volume: 26, P: 1280-1284
Broad threat to humanity from cumulative climate hazards intensified by greenhouse gas emissions

This Review examines the pathways through which humans are impacted by climate change and shows that by 2100 the world’s population will be simultaneously exposed to at least three hazards, and in some locations as many as six, under an RCP 8.5 scenario.

Camilo Mora
Daniele Spirandelli
Cynthia L. Hunter
Reviews19 Nov 2018
Nature Climate Change

Volume: 8, P: 1062-1071
Using metabarcoding and droplet digital PCR to investigate drivers of historical shifts in cyanobacteria from six contrasting lakes

Maïlys Picard
Xavier Pochon
Susanna A. Wood
ResearchOpen Access27 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Pacific decadal variability over the last 2000 years and implications for climatic risk

Negative phases of the Interdecadal Pacific Oscillation, which alters hydroclimatic risk across the Pacific, have been shorter and less frequent than inferred from the instrumental record, suggests a 2,000-year ice core reconstruction.

Tessa R. Vance
Anthony S. Kiem
Tas D. van Ommen
ResearchOpen Access17 Feb 2022
Communications Earth & Environment

Volume: 3, P: 1-9
An East Antarctic, sub-annual resolution water isotope record from the Mount Brown South Ice core

Vasileios Gkinis
Sarah Jackson
Tessa R. Vance
ResearchOpen Access10 Sept 2024
Scientific Data

Volume: 11, P: 1-16

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