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Advanced filters: Author: Christopher P. Tinworth Clear advanced filters

  • Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a productive ternary complex between the protein, PROTAC and ligase complex.

    • John D. Harling
    • Christopher P. Tinworth
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 14, P: 1-3