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Showing 1–12 of 12 results
Advanced filters: Author: Christopher Pepin Clear advanced filters
    • Christopher P. McKay
    • Owen B. Toon
    • James F. Kasting
    Reviews
    Nature
    Volume: 352, P: 489-496
  • UTe2 is a proposed intrinsic topological superconductor, but its quasiparticle surface band has not yet been visualized. Now this is achieved using quasiparticle interference imaging, revealing the symmetry of the superconducting order parameter.

    • Shuqiu Wang
    • Kuanysh Zhussupbekov
    • Qiangqiang Gu
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 1555-1562
  • Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.

    • Junbing Zhang
    • Md Yousuf Ali
    • Liron Bar-Peled
    Research
    Nature
    Volume: 641, P: 1048-1058
  • Glycogen Storage Disease 1a (Gsd1a) is an inherited disorder caused by glucose 6-phosphatase (G6Pase-α) deficiency and characterized by hypoglycaemia and high risk of liver cancer. Here the authors develop a mRNA-based G6Pase-α delivery therapy that is efficacious and safe in a mouse model of GSD1a.

    • Jingsong Cao
    • Minjung Choi
    • Paloma H. Giangrande
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

    • Jennifer Wessel
    • Audrey Y Chu
    • Mark O Goodarzi
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16
  • The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

    • Curtis Huttenhower
    • Dirk Gevers
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 207-214
  • The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

    • Barbara A. Methé
    • Karen E. Nelson
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 215-221
  • The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

    • Michele Vacca
    • Ioannis Kamzolas
    • Antonio Vidal-Puig
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1178-1196
  • The recent success of mRNA vaccines has boosted the prospects for the development of a new class of designer medicines based on mRNA. This Review discusses the multiple design parameters that need to be carefully considered to create highly effective mRNA medicines.

    • Mihir Metkar
    • Christopher S. Pepin
    • Melissa J. Moore
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 67-83