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Showing 1–8 of 8 results
Advanced filters: Author: Christopher S. Nabel Clear advanced filters

  • Trends in global H2 sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

    • Zutao Ouyang
    • Robert B. Jackson
    • Andy Wiltshire
    ResearchOpen Access
    Nature
    Volume: 648, P: 616-624

  • Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of the adenosine transporter ENT1 is involved in this immunosuppression and can be targeted to boost T cell function, tumor killing and immune checkpoint blockade.

    • Theodore J. Sanders
    • Christopher S. Nabel
    • Erica Houthuys
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 854-865

  • The spatial organization of cells in solid tumors is considered to be important for immune response and response to therapy. Here the authors use multiomics including spatial transcriptomics of human lung tumors prior to patients being treated and show among other things an association of stem-immunity hubs rich in stem-like CD8+ T cells with positive response to anti-PD-1 therapy.

    • Jonathan H. Chen
    • Linda T. Nieman
    • Nir Hacohen
    Research
    Nature Immunology
    Volume: 25, P: 644-658

  • Diehl et al. show that imbalance among nucleotide species is not sensed by canonical metabolic regulatory pathways, causing excessive cell growth despite a DNA replication block. ATR is needed to increase nucleotide availability in normal S phase.

    • Frances F. Diehl
    • Teemu P. Miettinen
    • Matthew G. Vander Heiden
    ResearchOpen Access
    Nature Cell Biology
    Volume: 24, P: 1252-1264

  • AID/APOBEC deaminases, which convert cytosine bases to uracils in DNA and RNA, have recently been assigned a role in epigenetic regulation as components of DNA demethylation pathways. A systematic study shows that AID/APOBEC enzymes preferentially deaminate unmodified cytosine over its C5-modified forms, calling into question the plausibility of deaminase-mediated DNA demethylation pathways.

    • Christopher S Nabel
    • Huijue Jia
    • Rahul M Kohli
    Research
    Nature Chemical Biology
    Volume: 8, P: 751-758

  • A massively parallel computational and experimental approach for de novo designing and screening small hyperstable proteins targeting influenza haemagglutinin and botulinum neurotoxin B identifies new therapeutic candidates more robust than traditional antibody therapies.

    • Aaron Chevalier
    • Daniel-Adriano Silva
    • David Baker
    Research
    Nature
    Volume: 550, P: 74-79