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Showing 1–4 of 4 results
Advanced filters: Author: Christopher Schliehe Clear advanced filters

  • Personalized neoantigen vaccines offer the potential to boost immune response a patient against their specific cancer antigens. Here, Katsikis, Ishii and Schliehe discuss the challenges that currently limit this therapeutic approach, including those related to neoantigen selection and adjuvants, and post-vaccine challenges such as the immunosuppressive tumour microenvironment. Moreover, they consider solutions that could help to overcome these obstacles.

    • Peter D. Katsikis
    • Ken J. Ishii
    • Christopher Schliehe
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 213-227

  • Infection with influenza virus can result in bacterial superinfection, but the mechanisms underlying this process are unclear. Bergthaler and colleagues demonstrate that influenza virus upregulates the methyltransferase Setdb2, which attenuates select proinflammatory gene expression and heightens susceptibility to bacterial infection.

    • Christopher Schliehe
    • Elizabeth K Flynn
    • Andreas Bergthaler
    Research
    Nature Immunology
    Volume: 16, P: 67-74