Nature Search

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but establish good ligandability of ATG8 isoforms through fragment screening and docking.

Martin P. Schwalm
Johannes Dopfer
Vladimir V. Rogov
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Reduced North American terrestrial primary productivity linked to anomalous Arctic warming

Anomalous Arctic warming has been linked to colder North American winters. Analyses of weather and productivity observations reveal that Arctic–North American teleconnections reduce gross primary productivity in the US.

Jin-Soo Kim
Jong-Seong Kug
Kevin Schaefer
Research10 Jul 2017
Nature Geoscience

Volume: 10, P: 572-576
Anthropogenic climate change contributes to wildfire particulate matter and related mortality in the United States

Climate change contributed to 15,000 wildfire particulate matter deaths in the United States between 2006 and 2020, with a cumulative economic burden of $160 billion, according to observation-based modelling of climate, wildfire particulate matter, health, and economic impacts

Beverly E. Law
John T. Abatzoglou
Nicholas J. Nassikas
ResearchOpen Access02 May 2025
Communications Earth & Environment

Volume: 6, P: 1-11
Reduction in carbon uptake during turn of the century drought in western North America

The severity and incidence of climatic extremes, including drought, have increased as a result of climate warming. Analyses of observational and reanalysis data suggest that the strength of the western North American carbon sink declined by 30–298 Tg carbon per year during the drought at the turn of the century.

Christopher R. Schwalm
Christopher A. Williams
Russel L. Scott
Research29 Jul 2012
Nature Geoscience

Volume: 5, P: 551-556
Enhanced peak growth of global vegetation and its key mechanisms

Combining two global datasets, the authors show that peak vegetation growth has been increasing linearly for the past 30 years, with similar proportions of NDVI variation attributable to expanding croplands, rising CO₂ and intensifying nitrogen deposition.

Kun Huang
Jianyang Xia
Yiqi Luo
Research12 Nov 2018
Nature Ecology & Evolution

Volume: 2, P: 1897-1905
Widespread spring phenology effects on drought recovery of Northern Hemisphere ecosystems

The authors reveal complex drought recovery responses to phenology shifts, in that early spring can shorten or lengthen recovery, while delayed spring following drought events delays it. These effects suggest a need to incorporate phenology aspects into resilience models.

Yang Li
Wen Zhang
Xiuchen Wu
ResearchOpen Access19 Jan 2023
Nature Climate Change

Volume: 13, P: 182-188
Field-experiment constraints on the enhancement of the terrestrial carbon sink by CO₂ fertilization

The northern temperate carbon sink is estimated to increase by 0.64 PgC each year for each increase in atmospheric CO₂ concentrations by 100 ppm, suggests an analysis of data from field experiments at 7 sites constraints.

Yongwen Liu
Shilong Piao
Tao Wang
Research02 Sept 2019
Nature Geoscience

Volume: 12, P: 809-814
Global patterns of drought recovery

A global analysis of gross primary productivity reveals that drought recovery is driven by climate and carbon cycling, with recovery longest in the tropics and high northern latitudes, and with impacts increasing over the twentieth century.

Christopher R. Schwalm
William R. L. Anderegg
Hanqin Tian
Research10 Aug 2017
Nature

Volume: 548, P: 202-205
Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain

The TRIM21 protein’s PRY-SPRY domain is crucial in immune response by recognizing and degrading intracellular antibodies, yet small-molecule targeting remains underexplored. Here, the authors use a crystallographic fragment screening to identify 109 fragment binders distributing across five distinct binding sites of TRIM21, improve the activity by a fragment merging approach, and establish a NanoBRET assay to enable functional validation of compounds.

Yeojin Kim
Aleksandar Lučić
Stefan Knapp
ResearchOpen Access13 Jun 2025
Communications Chemistry

Volume: 8, P: 1-11
Seasonal CO₂ amplitude in northern high latitudes

Changes in the seasonal cycle amplitude of atmospheric CO₂ (SCA) reflect large-scale changes in the global carbon cycle. This Review summarizes the positive SCA trend in the northern high latitudes, where the signal is strongest, and explores the underlying mechanisms driving the trend and their relative importance.

Zhihua Liu
Brendan M. Rogers
Yangjian Zhang
Reviews31 Oct 2024
Nature Reviews Earth & Environment

Volume: 5, P: 802-817
The terrestrial biosphere as a net source of greenhouse gases to the atmosphere

The net balance of terrestrial biogenic greenhouse gases produced as a result of human activities and the climatic impact of this balance are uncertain; here the net cumulative impact of the three greenhouse gases, methane, nitrous oxide and carbon dioxide, on the planetary energy budget from 2001 to 2010 is a warming of the planet.

Hanqin Tian
Chaoqun Lu
Steven C. Wofsy
Research09 Mar 2016
Nature

Volume: 531, P: 225-228
Compensatory water effects link yearly global land CO₂ sink changes to temperature

A study of how temperature and water availability fluctuations affect the carbon balance of land ecosystems reveals different controls on local and global scales, implying that spatial climate covariation drives the global carbon cycle response.

Martin Jung
Markus Reichstein
Ning Zeng
Research16 Jan 2017
Nature

Volume: 541, P: 516-520
Carbon and Water Use Efficiencies: A Comparative Analysis of Ten Terrestrial Ecosystem Models under Changing Climate

Bassil El Masri
Christopher Schwalm
Anna M. Michalak
ResearchOpen Access11 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Author Correction: Modeling suggests fossil fuel emissions have been driving increased land carbon uptake since the turn of the 20th Century

Christopher R. Schwalm
Deborah N. Huntzinger
Yaxing Wei
Amendments and CorrectionsOpen Access10 Aug 2020
Scientific Reports

Volume: 10, P: 1
Land carbon models underestimate the severity and duration of drought’s impact on plant productivity

Hannah R. Kolus
Deborah N. Huntzinger
Xiaoying Shi
ResearchOpen Access26 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Modeling suggests fossil fuel emissions have been driving increased land carbon uptake since the turn of the 20th Century

Christopher R. Schwalm
Deborah N. Huntzinger
Yaxing Wei
ResearchOpen Access03 Jun 2020
Scientific Reports

Volume: 10, P: 1-9
The FLUXCOM ensemble of global land-atmosphere energy fluxes

Martin Jung
Sujan Koirala
Markus Reichstein
ResearchOpen Access27 May 2019
Scientific Data

Volume: 6, P: 1-14

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