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Showing 1–13 of 13 results
Advanced filters: Author: Christos Samakovlis Clear advanced filters

  • Spatial transcriptomics relies on RNA quality, which is variable and dependent on sample handling, storage, and/or intrinsic factors. Here, authors present a genome-wide spatial gene expression profiling method called RNA Rescue Spatial Transcriptomics (RRST), designed for the analysis of moderate to low quality fresh frozen tissue samples and demonstrate its robustness on 7 different tissue types.

    • Reza Mirzazadeh
    • Zaneta Andrusivova
    • Joakim Lundeberg
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Polarity-deficient epithelial cells are eliminated through Sas-Ptp10D-mediated suppression of EGFR signalling during cell competition. Here the authors show the constitutively active, phosphomimetic WASH can activate both EGFR and Hippo signalling and thereby, induces the overgrowth of these polarity-deficient cells in Drosophila and in proliferating epithelial cells, WASH activation differentially affects the separate recycling routes of EGFR and its inhibitor Ptp10D.

    • Dan Liu
    • Vasilios Tsarouhas
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

    • Vasilios Tsarouhas
    • Dan Liu
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Spapros is a probe set selection pipeline for targeted spatial transcriptomics that optimizes for both transcriptional and within-cell type variation.

    • Louis B. Kuemmerle
    • Malte D. Luecken
    • Fabian J. Theis
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 2260-2270

  • Understanding the development of the lung will inform treatments for congenital diseases and approaches for preterm infant care. Here they map human lung development using high-parametric imaging at the single-cell level to track abundance, proliferation, and spatial organization of key cell types during early gestation.

    • Sanem Sariyar
    • Alexandros Sountoulidis
    • Burcu Ayoglu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.

    • Swati Dabral
    • Christian Muecke
    • Soni S. Pullamsetti
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The wound-healing transcription factor Grainy head upregulates a receptor tyrosine kinase of the Ret-family, Stitcher. Stitcher orchestrates re-epithelialization by triggering rearrangements of the actin cytoskeleton and changes in gene expression through Erk phosphorylation and regulation of Grainy head activity.

    • Shenqiu Wang
    • Vasilios Tsarouhas
    • Christos Samakovlis
    Research
    Nature Cell Biology
    Volume: 11, P: 890-895

  • Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.

    • Linh T. Bui
    • Nichelle I. Winters
    • Laure Emmanuelle Zaragosi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559