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Showing 1–3 of 3 results
Advanced filters: Author: Chrysoula Daskalogianni Clear advanced filters

  • Cells infected with Epstein-Barr virus (EBV) express the virus-encoded EBNA1, which is essential for viral genome maintenance but also highly antigenic. Here the authors implicate nucleolin as a host factor that mediates the repression of EBNA1-derived antigenic peptides through binding of the G4-quadruplex structure present within the EBNA1 mRNA.

    • María José Lista
    • Rodrigo Prado Martins
    • Marc Blondel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.

    • Sivakumar Vadivel Gnanasundram
    • Slovénie Pyndiah
    • Robin Fåhraeus
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • The ubiquitin ligase Mdm2 promotes both proteolytic degradation of the tumour suppressor p53 and its translation. Fahraeus and colleagues report an additional layer of regulation: p53 mRNA binds directly to Mdm2 protein to inhibit ubiquitin ligase activity, promoting its own translation.

    • Marco M. Candeias
    • Laurence Malbert-Colas
    • Robin Fåhraeus
    Research
    Nature Cell Biology
    Volume: 10, P: 1098-1105