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Showing 1–5 of 5 results
Advanced filters: Author: Chuna Kim Clear advanced filters

  • Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

    • Jae Sook Kang
    • Jung Ha Kim
    • Yong Ryoul Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres maintained with non-telomeric sequences.

    • Chuna Kim
    • Sanghyun Sung
    • Junho Lee
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Telomeres in post-crisis cells are maintained by re-activated telomerase or by alternative lengthening of telomeres (ALT). Here, Seo et al. report a stable mode of ALT in worm where internal genomic regions generate a genomic reservoir ready to be incorporated into telomeres upon ALT activation.

    • Beomseok Seo
    • Chuna Kim
    • Junho Lee
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Tissue aging is associated with pro-fibrotic changes and stiffening of the extracellular matrix. Here the authors present FiNi-seq, a method that enriches fibrotic tissue based on its physical properties and thus captures aging-associated cell types. The study characterizes early fibrotic changes in liver tissue.

    • Kwon Yong Tak
    • Juyeon Kim
    • Jong-Eun Park
    Research
    Nature Aging
    Volume: 5, P: 929-949