In this work, an anticancer drug, metformin, has been used to promote DNA single strands to assemble into well-defined DNA nanostructures. The resulting metformin-DNA complex nanostructures can simultaneously deliver metformin and KRAS siRNA to synergistically treat KRAS-mutated, non-small cell lung cancer in vivo.
- Hang Qian
- Dong Wang
- Guansong Wang
