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Showing 1–5 of 5 results

Advanced filters: Author: Chunting Fu Clear advanced filters

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Tian Zhang
Weixin Fu
Junying Yuan
Research07 Nov 2024
Nature Cell Biology

Volume: 26, P: 2099-2114
Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding

It is common to engineer membrane proteins for cryo-EM analysis. Here, the authors report a cryo-EM structure of an engineered, functional VMAT2 with a non-canonical fold. Caution is advised when interpreting engineered membrane protein structures.

Ying Lyu
Chunting Fu
Xiaoming Zhou
ResearchOpen Access02 Aug 2024
Nature Communications

Volume: 15, P: 1-9
Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor

How endogenous ligands bind to the sigma-1 receptor (σ1R) remains elusive. Here, the authors report crystal structures of σ1R from Xenopus laevis bound to two neurosteroid ligands, providing insight into their binding mechanism to σ1R.

Chunting Fu
Yang Xiao
Ziyi Sun
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis

Lihua Shao
Li Zhu
Hailong Li
ResearchOpen Access10 May 2024
Scientific Reports

Volume: 14, P: 1-13
The Medicago genome provides insight into the evolution of rhizobial symbioses

Sequencing of Medicago truncatula, a model organism of legume biology, shows that genome duplications had a role in the evolution of endosymbiotic nitrogen fixation.

Nevin D. Young
Frédéric Debellé
Bruce A. Roe
ResearchOpen Access16 Nov 2011
Nature

Volume: 480, P: 520-524