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Advanced filters: Author: Clémence Gruget Clear advanced filters

Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension

Bacterial homologous recombination involves the actions of RadA and RecA to promote single-stranded DNA integration. Here the authors report the structure of RadA fromStreptococcus pneumoniaeand demonstrate that it acts as a hexameric DnaB-type helicase.

Léa Marie
Chiara Rapisarda
Patrice Polard
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-14
A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease

Missense mutations at a pivotal domain interface of the bile salt export pump (BSEP) lead to structural and thermodynamic destabilization, impairing protein trafficking and contributing to cholestatic disease pathogenesis

Clémence Gruget
Bharat G. Reddy
Jonathan M. Moore
ResearchOpen Access07 Apr 2025
Communications Biology

Volume: 8, P: 1-12
Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain

Clémence Gruget
Oscar Bello
Stephen H. Donaldson Jr
ResearchOpen Access22 Oct 2020
Scientific Reports

Volume: 10, P: 1-10