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Showing 1–4 of 4 results
Advanced filters: Author: Clément Campillo Clear advanced filters
  • The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.

    • Isma Bennabi
    • Flora Crozet
    • Marie-Emilie Terret
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • The same type of polymer network deforms cell membranes inward, to absorb external material, and outward, to facilitate signal transmission. Experiments and theory show that these deformations are regulated by membrane tension and network mesh size.

    • Camille Simon
    • Rémy Kusters
    • Cécile Sykes
    Research
    Nature Physics
    Volume: 15, P: 602-609
  • Verlhac, Terret and colleagues report that softening of the mouse oocyte cortex during meiosis I is needed for spindle migration and positioning. They show that Mos/mAPK signalling triggers myosin II exclusion from the cortex and an Arp2/3-dependent cortical F-actin thickening that contributes to cortical softening.

    • Agathe Chaigne
    • Clément Campillo
    • Marie-Emilie Terret
    Research
    Nature Cell Biology
    Volume: 15, P: 958-966
  • How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension.

    • Agathe Chaigne
    • Clément Campillo
    • Marie-Emilie Terret
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14