Nature Search

Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in Crohn's Disease

Claire Fraser-Liggett
ResearchOpen Access12 Oct 2010
Nature Precedings

P: 1
The Thrifty Microbiome: The Role of the Gut Microbiota in Obesity in the Amish

Claire Fraser-Liggett
Alan Shuldiner
ResearchOpen Access12 Oct 2010
Nature Precedings

P: 1
National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-14
A model for high-throughput automated DNA sequencing and analysis core facilities

Large-scale DNA sequencing and analysis is providing important molecular information on complex biological systems.

Mark D. Adams
Anthony R. Kerlavage
J. Craig Venter
Comments & Opinion31 Mar 1994
Nature

Volume: 368, P: 474-475
The microbiome explored: recent insights and future challenges

Here, Blaser, Bork, Fraser, Knight and Wang highlight the most exciting findings in the field of microbiome research and discuss what will be necessary to obtain a better understanding of the role of the microbiota in human health and disease, and to develop microbiota-based therapies.

Martin Blaser
Peer Bork
Jun Wang
Reviews04 Feb 2013
Nature Reviews Microbiology

Volume: 11, P: 213-217
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

Here the authors show that lung epithelial, fibroblast, and endothelial cells retain an imprint of influenza A infection, including increased MHCI/II expression and that re-infection is quickly controlled by a localized antiviral response acting before memory T cells are required.

Julie C. Worrell
Kerrie E. Hargrave
Megan K. L. MacLeod
ResearchOpen Access01 Aug 2025
Nature Communications

Volume: 16, P: 1-21
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Designing minimal genomes using whole-cell models

Genome engineering will one day benefit from computational tools that can design genomes with desired functions. Here the authors develop computational design-simulate-test algorithms to design minimal genomes based on the whole-cell model of Mycoplasma genitalium.

Joshua Rees-Garbutt
Oliver Chalkley
Claire Grierson
ResearchOpen Access11 Feb 2020
Nature Communications

Volume: 11, P: 1-12
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

Nathalie Neyroud
Frédérique Tesson
Pascale Guicheney
Research01 Feb 1997
Nature Genetics

Volume: 15, P: 186-189
Politics and Religion in India

K. DE B. CODRINGTON
Research02 Sept 1933
Nature

Volume: 132, P: 349-350
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Erratum: The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans-Peter Klenk
Rebecca A. Clayton
J. Craig Venter
Amendments and CorrectionsOpen Access01 Jul 1998
Nature

Volume: 394, P: 101
Erratum: The complete genome sequence of the gastric pathogen Helicobacter pylori

Jean-F. Tomb
Owen White
J. Craig Venter
Amendments and Corrections25 Sept 1997
Nature

Volume: 389, P: 412
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Correction: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

William C. Nierman
Arnab Pain
David W. Denning
Amendments and Corrections26 Jan 2006
Nature

Volume: 439, P: 502
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Collaborative genomics for human health and cooperation in the Mediterranean region

Tayfun Özçelik
Moien Kanaan
Ephrat Levy-Lahad
Comments & Opinion01 Aug 2010
Nature Genetics

Volume: 42, P: 641-645
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Change in dominance determines herbivore effects on plant biodiversity

Evidence synthesized from 252 large-herbivore exclusion studies suggests that herbivore-induced change in dominance, independent of site productivity or precipitation, best predicts herbivore effects on biodiversity in grassland and savannah sites.

Sally E. Koerner
Melinda D. Smith
Tamara Jane Zelikova
Research29 Oct 2018
Nature Ecology & Evolution

Volume: 2, P: 1925-1932
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

Xiaoying Lin
Samir Kaul
J. Craig Venter
Research16 Dec 1999
Nature

Volume: 402, P: 761-768
Large-scale migration into Britain during the Middle to Late Bronze Age

Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

Nick Patterson
Michael Isakov
David Reich
Research22 Dec 2021
Nature

Volume: 601, P: 588-594
Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

Malcolm J. Gardner
Shamira J. Shallom
Claire M. Fraser
Research03 Oct 2002
Nature

Volume: 419, P: 531-534
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Author Correction: Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint

Judy C. Boughey
Michael D. Alvarado
Kathleen Kemmer
Amendments and CorrectionsOpen Access02 Jan 2019
npj Breast Cancer

Volume: 5, P: 1
Correction: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Colin S Cooper
Rosalind Eeles
David E Neal
Amendments and Corrections27 May 2015
Nature Genetics

Volume: 47, P: 689
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

Claire M. Fraser
Sherwood Casjens
J. Craig Venter
Research01 Dec 1997
Nature

Volume: 390, P: 580-586
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans-Peter Klenk
Rebecca A. Clayton
J. Craig Venter
Research27 Nov 1997
Nature

Volume: 390, P: 364-370
The complete genome sequence of the gastric pathogen Helicobacter pylori

Jean-F. Tomb
Owen White
J. Craig Venter
Research07 Aug 1997
Nature

Volume: 388, P: 539-547
The genome of the protist parasite Entamoeba histolytica

Brendan Loftus
Iain Anderson
Neil Hall
ResearchOpen Access24 Feb 2005
Nature

Volume: 433, P: 865-868
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana

Athanasios Theologis
Joseph R. Ecker
Ronald W. Davis
Research14 Dec 2000
Nature

Volume: 408, P: 816-820
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

William C. Nierman
Arnab Pain
David W. Denning
Research22 Dec 2005
Nature

Volume: 438, P: 1151-1156
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

Philip J. Law
Sonja I. Berndt
Susan Slager
ResearchOpen Access06 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution

Elodie Ghedin
Naomi A. Sengamalay
Steven L. Salzberg
ResearchOpen Access05 Oct 2005
Nature

Volume: 437, P: 1162-1166
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes
Jeffrey C Barrett
Christopher G Mathew
Research06 Jun 2007
Nature Genetics

Volume: 39, P: 830-832
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila

Mitochondrial fission, performed by Drp1, is carefully regulated, particularly in neurons. Here, the authors examine Drosophila Cdk8/CDK19 function in mitochondrial fission and uncover a role phosphorylating Drp1 in the cytoplasm and show overexpression suppresses a Parkinson’s disease model.

Jenny Zhe Liao
Hyung-lok Chung
Esther M. Verheyen
ResearchOpen Access18 Apr 2024
Nature Communications

Volume: 15, P: 1-19
Social–environmental drivers inform strategic management of coral reefs in the Anthropocene

Surveys from 2,584 sites across the Indo-Pacific identify key climate, socioeconomic and environmental drivers associated with hard coral assemblages. This informs a strategic approach to protect, recover or transform coral reef management.

Emily S. Darling
Tim R. McClanahan
David Mouillot
Research12 Aug 2019
Nature Ecology & Evolution

Volume: 3, P: 1341-1350
Sequenced strains must be saved from extinction

Naomi Ward
Jonathan Eisen
Erko Stackebrandt
Correspondence08 Nov 2001
Nature

Volume: 414, P: 148
Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Jane M. Carlton
John H. Adams
Claire M. Fraser-Liggett
ResearchOpen Access09 Oct 2008
Nature

Volume: 455, P: 757-763
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Unsuspected diversity among marine aerobic anoxygenic phototrophs

Oded Béjà
Marcelino T. Suzuki
Edward F. DeLong
ResearchOpen Access07 Feb 2002
Nature

Volume: 415, P: 630-633
Newly detected ozone-depleting substances in the atmosphere

Ozone-depleting substances emitted through human activities cause large-scale damage to the stratospheric ozone layer, and influence global climate. An analysis of unpolluted air sampled from Tasmania and firn snow reveals the emergence of four new ozone-depleting substances in the atmosphere since the 1960s.

Johannes C. Laube
Mike J. Newland
William T. Sturges
Research09 Mar 2014
Nature Geoscience

Volume: 7, P: 266-269
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

Jean-Marc Taymans
Eugénie Mutez
Marie-Christine Chartier-Harlin
ResearchOpen Access07 Feb 2023
npj Parkinson's Disease

Volume: 9, P: 1-14
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

An exciting genome-wide association study in the British population for seven common diseases. This analysis confirms previously identified loci and provides strong evidence for many novel disease susceptibility loci.

Paul R. Burton
David G. Clayton
Jane Worthington
Research07 Jun 2007
Nature

Volume: 447, P: 661-678
Adaptations of avian flu virus are a cause for concern

Members of the US National Science Advisory Board for Biosecurity explain its recommendations on the communication of experimental work on H5N1 influenza.

Kenneth I. Berns
Arturo Casadevall
Anne K. Vidaver
Comments & Opinion31 Jan 2012
Nature

Volume: 482, P: 153-154

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