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Showing 1–2 of 2 results
Advanced filters: Author: Claire Giry Clear advanced filters

  • Until today, genetic tools have been lacking to enable manipulation of amoebal giant viruses (GVs) by CRISPR/Cas9 technology. Here, Bisio et al. apply S. pyogenes Cas9 together with pU6- driven guide RNAs to investigate the replication of pandoravirus, a GV replication in the nucleus. Using this tool, they provide evidence for stepwise evolution and genetic expansion of viral gigantism.

    • Hugo Bisio
    • Matthieu Legendre
    • Chantal Abergel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings  are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.

    • Andreia V. Pinho
    • Mathias Van Bulck
    • Ilse Rooman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14