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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic epiblast. They establish naïve embryonic stem cells based on these insights.

Claire S. Simon
Afshan McCarthy
Kathy K. Niakan
ResearchOpen Access28 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare syndrome. Casanova and colleagues characterize MSMD in two kindreds and find macrophage-tropic mutations in genes encoding the respiratory burst machinery predispose these kindreds to mycobacterial diseases.

Jacinta Bustamante
Andres A Arias
Jean-Laurent Casanova
Research30 Jan 2011
Nature Immunology

Volume: 12, P: 213-221
Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney

Ekin Yagis
Shahab Aslani
Claire L. Walsh
ResearchOpen Access08 Nov 2024
Scientific Reports

Volume: 14, P: 1-24
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites

Computational analyses and molecular genetics reveal that integron cassettes integrate into bacterial genomes at widespread non-classical attG sites, enabling acquisition of genetic material and disruption of existing genes with potential consequences for bacterial evolution.

Céline Loot
Gael A. Millot
Didier Mazel
Research03 Jan 2024
Nature Microbiology

Volume: 9, P: 228-240
Comment l'ignorance et l'inégalité entre les sexes entravent le traitement d'une maladie très répandue

Des dizaines de millions de personnes sont atteintes de schistosomiase génitale féminine, une maladie tropicale négligée dont peu de médecins ont entendu parler. Des efforts sont en cours pour sortir cette maladie de l'ombre et permettre aux femmes et aux jeunes filles d'accéder aux soins de santé sexuelle et génésique.

Claire Ainsworth
News17 May 2024
Nature Africa
Immunopathological manifestations in Kabuki syndrome: a registry study of 177 individuals

Henri Margot
Guilaine Boursier
David Geneviève
Research31 Jul 2019
Genetics in Medicine

Volume: 22, P: 181-188
Factors associated with serum 25-hydroxyvitamin D concentrations in older people in Europe: the EUREYE study

Claire Casey
Jayne V. Woodside
A. E. Fletcher
Research26 Oct 2018
European Journal of Clinical Nutrition

Volume: 73, P: 319-328

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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney

Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites

Comment l'ignorance et l'inégalité entre les sexes entravent le traitement d'une maladie très répandue

Immunopathological manifestations in Kabuki syndrome: a registry study of 177 individuals

Factors associated with serum 25-hydroxyvitamin D concentrations in older people in Europe: the EUREYE study

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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney

Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites

Comment l'ignorance et l'inégalité entre les sexes entravent le traitement d'une maladie très répandue

Immunopathological manifestations in Kabuki syndrome: a registry study of 177 individuals

Factors associated with serum 25-hydroxyvitamin D concentrations in older people in Europe: the EUREYE study

Search

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