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Showing 1–5 of 5 results
Advanced filters: Author: Clara L. Essmann Clear advanced filters

  • Little is known on how solid tumours overcome growth inhibitory signals within its hypoxic microenvironment. Here Henze et al.show that oxygen sensor PHD3 is frequently lost in gliomas, and that this loss hyperactivates EGFR signaling to sustain tumour cell proliferation and survival in hypoxia.

    • Anne-Theres Henze
    • Boyan K. Garvalov
    • Till Acker
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • The shuttling of AMPA receptors to and from the synaptic membrane determines the strength of synaptic transmission. This study shows that ephrinB2 is part of the mechanism that stabilizes AMPA receptors at the synaptic surface. EphrinB2 and AMPA receptors are linked by two PDZ domains in the intracellular adaptor protein GRIP.

    • Clara L Essmann
    • Elsa Martinez
    • Amparo Acker-Palmer
    Research
    Nature Neuroscience
    Volume: 11, P: 1035-1043

  • The protein ephrin-B2 is known to be upregulated during angiogenesis — the growth of new blood vessels — but its precise function has been unclear. Here it is shown that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating the internalization of vascular endothelial growth factor receptors (VEGFRs). The results indicate that blocking ephrin-B2 signalling might be an alternative to blocking VEGFR function to disrupt angiogenesis in tumours.

    • Suphansa Sawamiphak
    • Sascha Seidel
    • Amparo Acker-Palmer
    Research
    Nature
    Volume: 465, P: 487-491