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Showing 1–2 of 2 results
Advanced filters: Author: Clara Ponsolles Clear advanced filters

  • Here, using human liver chimeric mice, the authors describe perturbation of the diurnal transcriptome and epigenome of human hepatocytes during hepatitis C virus infection, affecting pathways mediating metabolic alterations, fibrosis, and cancer, and further show that the pathways remain affected in patients with advanced liver disease.

    • Atish Mukherji
    • Frank Jühling
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.

    • Emilie Crouchet
    • Simonetta Bandiera
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19