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Showing 1–6 of 6 results
Advanced filters: Author: Clare A. Notley Clear advanced filters

  • The International Mouse Phenotyping Consortium (IMPC) aims to identify the function of all protein-coding genes in the mouse genome. Hayday and colleagues leverage 530 knockout lines from the IPMC to develop the 3i Project, which immunophenotypes mice and leads to the identification of new and unexpected gene influences on immune function and on the structural organization of the immune system.

    • Lucie Abeler-Dörner
    • Adam G. Laing
    • Adrian C. Hayday
    Research
    Nature Immunology
    Volume: 21, P: 86-100

  • Regulatory T (TREG) cells, which function as suppressors of autoimmune responses, are defective in patients with rheumatoid arthritis (RA). In this article, the authors describe the interplay between TREG cells and inflammation in the context of RA, and how a subset of highly potent but unstable TREGcells seems to be induced following tumor necrosis factor blockade.

    • Clare A. Notley
    • Michael R. Ehrenstein
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 572-577

  • Natural IgM has many roles in the immune system, from protection against infection to regulating autoimmunity. The authors discuss the pleiotropic properties of natural IgM, and the implications for B cell-targeted therapy.

    • Michael R. Ehrenstein
    • Clare A. Notley
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 778-786