Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signalling pathways are involved in a vast array of cellular events and are often altered in human cancers. This Review discusses how studies in mouse models have contributed to our understanding of the functions of these pathways in different cancers, and the implications for therapeutic approaches.
- Erwin F. Wagner
- Ángel R. Nebreda
