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Showing 1–6 of 6 results
Advanced filters: Author: Clare S Hardman Clear advanced filters

  • Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and systemic inflammatory disease, and the generalized symptoms could be alleviated by blocking antibodies developed against CD1a.

    • Clare S. Hardman
    • Yi-Ling Chen
    • Graham S. Ogg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • The antibody response during infection with dengue virus is a key component involved in the pathogenesis during secondary infection. Here the authors show antibodies targeting NS1 and the epitopes targeted can be associated with disease severity during human infection.

    • Deshni Jayathilaka
    • Laksiri Gomes
    • Gathsaurie Neelika Malavige
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Nuocytes are innate cells with critical roles during infection with parasitic worms. McKenzie and colleagues show that nuocytes differentiate from common lymphoid progenitors and require IL-7, IL-33, Notch and RORα for development.

    • See Heng Wong
    • Jennifer A Walker
    • Andrew N J McKenzie
    Research
    Nature Immunology
    Volume: 13, P: 229-236

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Group 2 innate lymphoid cells are activated during acute dengue viral infection in human, downregulate type I-IFN responsive gene and protein expression through Prostaglandin D2, and are permissive for productive dengue viral infection.

    • Chathuranga L. Fonseka
    • Clare S. Hardman
    • Graham S. Ogg
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15