Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Clare Y. Slaney Clear advanced filters

  • Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

    • Jack D. Chan
    • Christina M. Scheffler
    • Phillip K. Darcy
    ResearchOpen Access
    Nature
    Volume: 629, P: 201-210

  • The authors identify Irf7 and associated interferon signaling as an important factor suppressing bone metastasis of breast cancers. Irf7 is lost in experimental metastasis and human bone metastastic tissue, and this fosters an immunosuppressive environment that facilitates metastasis. Manipulating this innate immune signaling pathway emerging from tumor cells by interferon administration had beneficial effects in mouse models by reducing bone metastasis and increasing survival time.

    • Bradley N Bidwell
    • Clare Y Slaney
    • Belinda S Parker
    Research
    Nature Medicine
    Volume: 18, P: 1224-1231

  • The understanding of molecular mechanisms in different subtypes of head and neck cancer (HNC) will define subtype-specific treatment options. Here the authors show that PI3K-phospho-YBX1 axis promotes tumour growth in basal subtype of HNC, while unphosphorylated YBX1 acts as a suppressor of metastasis in the mesenchymal subtype with inactive PI3K signalling.

    • Yuchen Bai
    • Carolin Gotz
    • Charbel Darido
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Successful adoptive cell therapy for cancer depends on the expansion and persistence of tumour-specific T cells with stem-like memory or precursor characteristics. Here, the authors describe approaches to generate these cells by in vitro culture methods, by modulating transcriptional, metabolic and/or epigenetic programming, and by fine-tuning antigen receptor signalling.

    • Jack D. Chan
    • Junyun Lai
    • Phillip K. Darcy
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 769-784