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Showing 1–7 of 7 results
Advanced filters: Author: Clarence Y. Cheng Clear advanced filters
  • Simultaneous profiling of RNA and chromatin accessibility in single nuclei isolated from human postnatal brain regions from infancy to late adulthood identifies key cellular regulators and nominates target genes and mechanisms for brain-related diseases and disorders.

    • Tereza Clarence
    • Jaroslav Bendl
    • Panos Roussos
    Research
    Nature Genetics
    Volume: 57, P: 591-603
  • Photodynamic immunotherapy is promising for cancer therapy, but its efficacy is often hampered by hypoxia and immunosuppressive conditions within the tumor microenvironment. Here, the authors report the design guidelines for efficient Type-I semiconducting polymer photosensitizers and the development of a hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy.

    • Jie Yu
    • Jiayan Wu
    • Yan Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

    • Puya Gharahkhani
    • Eric Jorgenson
    • Janey L. Wiggs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

    • Pradeep Natarajan
    • Akhil Pampana
    • Gina M. Peloso
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

    • Richard M. Durbin
    • David Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 467, P: 1061-1073
  • A hybrid molecular motor made of an engineered protein and an RNA lever arm shows bidirectional transport controlled by oligonucleotide signals.

    • Tosan Omabegho
    • Pinar S. Gurel
    • Zev Bryant
    Research
    Nature Nanotechnology
    Volume: 13, P: 34-40