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Showing 1–4 of 4 results
Advanced filters: Author: Claudia Arbore Clear advanced filters

  • Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.

    • Giuseppina Arbore
    • Erin E. West
    • Claudia Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Recent studies have shown that complement activation is not confined to the serum but also occurs within cellular compartments. This has led to an emerging understanding that complement components can intersect diverse cellular metabolic and effector pathways. Here, the authors propose that the different locations of complement activation dictate its diverse functions.

    • Martin Kolev
    • Gaelle Le Friec
    • Claudia Kemper
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 811-820

  • Myosin-5B is an actin-based motor important for endosome recycling, but the molecular mechanism underlying its motility remains unknown. Here authors use single molecule imaging and high-speed laser tweezers to dissect the mechanoenzymatic properties of myosin-5B, which shows processive motility with peculiar mechanosensitivity.

    • Lucia Gardini
    • Sarah M. Heissler
    • Marco Capitanio
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12