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Nature Immunology (2)
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Advanced filters: Author: Claudia Bossen Clear advanced filters

CTCF-binding elements mediate control of V(D)J recombination

Chunguang Guo
Hye Suk Yoon
Frederick W. Alt
Research11 Sept 2011
Nature

Volume: 477, P: 424-430
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate

Lineage development is accompanied by specification of gene expression. Murre and colleagues show that during B cell development, many genes relocate in the nucleus, driven by chromatin-looping interactions with transcription factors.

Yin C Lin
Christopher Benner
Cornelis Murre
Research14 Oct 2012
Nature Immunology

Volume: 13, P: 1196-1204
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth

B lineage development requires the transcription factors E2A, EBF1, Foxo1 and Ikaros. Murre and colleagues show that these factors gain access to lineage-specific enhancer sites by the action of the chromatin remodeler Brg1.

Claudia Bossen
Caroline S Murre
Cornelis Murre
Research18 May 2015
Nature Immunology

Volume: 16, P: 775-784