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Showing 1–2 of 2 results
Advanced filters: Author: Claudia Galosi Clear advanced filters

  • In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pulmonary infection.

    • Silvia Moretti
    • Giorgia Renga
    • Luigina Romani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.

    • Rossana G. Iannitti
    • Valerio Napolioni
    • Luigina Romani
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16