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Showing 1–3 of 3 results
Advanced filters: Author: Claudia Loetsch Clear advanced filters

  • Experiments in mice show that a LINE-1 transposable element, Lx9c11, has a functional role in immunity by negatively regulating the response to viral infection to protect the host from an over-reactive immune response.

    • Nenad Bartonicek
    • Romain Rouet
    • Cecile King
    Research
    Nature
    Volume: 608, P: 757-765

  • A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human variants of TNFAIP3, which lower A20 activity and increase autoinflammatory responses. These alleles were inherited by descendants of Denisovans who crossed the Wallace Line to inhabit Oceania.

    • Nathan W. Zammit
    • Owen M. Siggs
    • Shane T. Grey
    Research
    Nature Immunology
    Volume: 20, P: 1299-1310

  • Interleukin-2 (IL-2) is a T-cell proliferating factor used for cancer immunotherapy. Here, the authors develop a long-lived variant of IL-2 that, mutated in its binding domain, drives a much more potent tumour regression by depleting CD25+ CD4+regulatory T-cells via targeting them for phagocytosis.

    • Rodrigo Vazquez-Lombardi
    • Claudia Loetsch
    • Daniel Christ
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12