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Fiber-specific differences in protein content of pathways related to mTORC1 signaling and oxidative metabolism in individuals with obesity

Cristian Campos
Marcelo Flores-Opazo
Luis Peñailillo
ResearchOpen Access04 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
γδ T cell distribution in the adventitial layer of non-fertile cystic echinococcosis cysts from cattle livers

Caroll Stoore
María Soledad Baquedano
Rodolfo Paredes
ResearchOpen Access28 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Lorena Pérez
Alejandro Vallejos
Felipe Simon
Amendments and Corrections15 Jan 2020
Laboratory Investigation

Volume: 100, P: 789
Metabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity

Rodrigo Fernández-Verdejo
Juan Gutiérrez-Pino
Jose E. Galgani
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

During endotoxemia, bacterial endotoxin interacts with vascular endothelial cells of blood vessels, generating endotoxin-induced endothelial fibrosis. Inhibition of endotoxemia-induced endothelial fibrosis increases the survival rate of endotoxemic rats by reversing the decreases in blood pressure associated with MODS, and inhibition of both oxidative bursts and pro-inflammatory cytokine secretion. These results suggest a novel target that may be used to generate therapeutic alternatives to lower the mortality of septic patients.

Alejandro Vallejos
Pedro Olivares
Felipe Simon
Research25 Mar 2019
Laboratory Investigation

Volume: 99, P: 1173-1192
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against endotoxemia-induced kidney injury potentially by means of endothelial hyperpermeability decreasing. Remarkably, TRPM7 inhibition improves survival in endotoxemic animals.

Sebastian Gatica
Vicente Villegas
Felipe Simon
Research23 Aug 2019
Laboratory Investigation

Volume: 100, P: 234-249
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Systemic inflammation generates oxidized high-density lipoprotein (oxHDL) inducing endothelial malfunction mediated by the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). OxHDL interacts with LOX-1 and increases LOX-1 levels to the plasma membrane through the NOX-2/ROS/NF-κB pathway. Oxidative stress is able to induce LOX-1 expression in absence of oxHDL. Also, oxHDL induces TNF-α expression increase, which induces LOX-1 expression.

Lorena Pérez
Alejandro Vallejos
Felipe Simon
Research21 Jan 2019
Laboratory Investigation

Volume: 99, P: 421-437
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Daniel Cabrera
Alexander Wree
Marco Arrese
ResearchOpen Access14 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway

Alvaro Becerra
Macarena Rojas
Felipe Simon
Research24 Jul 2017
Laboratory Investigation

Volume: 97, P: 1033-1046
Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway

Ignacio Montorfano
Alvaro Becerra
Felipe Simon
Research28 Jul 2014
Laboratory Investigation

Volume: 94, P: 1068-1082

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Fiber-specific differences in protein content of pathways related to mTORC1 signaling and oxidative metabolism in individuals with obesity

γδ T cell distribution in the adventitial layer of non-fertile cystic echinococcosis cysts from cattle livers

Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Metabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity

Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway

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