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Showing 1–6 of 6 results
Advanced filters: Author: Claudio Ponticelli Clear advanced filters

  • Antibodies against several podocyte antigens have evolved as markers of diagnosis, disease activity, and prognosis in membranous nephropathy, but their pathogenic role remains debated. Detailed work-up of two cases of primary and secondary membranous nephropathy now supports the concept that thrombospondin type-1 domain-containing 7A autoantibodies are pathogenic.

    • Hans-Joachim Anders
    • Claudio Ponticelli
    News & Views
    Nature Reviews Nephrology
    Volume: 12, P: 447-448

  • Medication errors frequently occur in the treatment of patients with renal insufficiency and can cause serious adverse events. Although computerized systems that adjust the drug dose on the basis of a patient's glomerular filtration rate can reduce the incidence and severity of drug prescription errors, other variables can also affect the susceptibility of patients with renal dysfunction to drug toxicity.

    • Claudio Ponticelli
    • Giorgio Graziani
    News & Views
    Nature Reviews Nephrology
    Volume: 6, P: 317-318

  • Ali Gharavi and colleagues report a genome-wide association analysis of IgA nephropathy in over 20,000 individuals of European and East Asian ancestry. They identify genome-wide significant signals at three new loci near VAV3, CARD9 and ITGAM-ITGAX and correlations between genetic risk and pathogen diversity.

    • Krzysztof Kiryluk
    • Yifu Li
    • Ali G Gharavi
    Research
    Nature Genetics
    Volume: 46, P: 1187-1196

  • The AURORA 1 study reports that low-dose voclosporin added to standard immunosuppressive treatment improved rate of remission in patients with lupus nephritis. Further studies are needed to investigate the long-term efficacy and tolerability of voclosporin and to compare the effects of this treatment with those of low doses of tacrolimus or ciclosporin.

    • Gabriella Moroni
    • Claudio Ponticelli
    News & Views
    Nature Reviews Nephrology
    Volume: 17, P: 637-638