A 37-year-old female was given esomeprazole to treat reflux-like dyspeptic symptoms ∼3 years after undergoing surgery for a neuroendocrine pancreatic neoplasm. During esomeprazole treatment, her serum chromogranin A level rose to around three times the upper limit of normal, but her gastrin levels remained in the normal range. Relapse of the neuroendocrine tumor was suspected; however, investigations led to a diagnosis of esomeprazole-induced hyperchromograninemia in the absence of elevated levels of fasting serum gastrin.
- Giovanni Gori
- Giacomo Spinelli
- Mario Del Tacca
