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Showing 1–7 of 7 results
Advanced filters: Author: Clemens Ruppert Clear advanced filters

  • Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform integrating RNA-binding proteome analyses and protein interactomes to map the lncRNA target network in human primary macrophages to build a searchable atlas of lncRNA.

    • Nils Schmerer
    • Harshavardhan Janga
    • Leon N. Schulte
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits immunopathology in a mouse model of the disease.

    • Kerstin Göbel
    • Susann Pankratz
    • Sven G. Meuth
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Knowledge of the energy transfer pathways in transition metal dichalcogenides is essential to design efficient optoelectronic devices. Here, the authors use megaelectronvolt ultrafast electron diffraction to unveil the sub-picosecond lattice dynamics in MoSe2 following photoexcitation of charge carriers

    • Ming-Fu Lin
    • Vidya Kochat
    • Uwe Bergmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models

    • Astrid Weiss
    • Moritz Christian Neubauer
    • Ralph Theo Schermuly
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activity and altered matrix remodeling.

    • Hyun-Taek Kim
    • Wenguang Yin
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13