Nature Search

Injury-induced Synthesis of Deoxyribonucleic Acid in the Lens of the Sea Bass

HOWARD ROTHSTEIN
CLIFFORD V. HARDING
Research21 Apr 1962
Nature

Volume: 194, P: 294-295
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

John D. Pfeifer
Mary Jo Wick
Clifford V. Harding
Research28 Jan 1993
Nature

Volume: 361, P: 359-362
Disappearance of Tritiated Thymidine and Tritiated Water from the Anterior Chamber of the Rabbit Eye

RONALD M. MAENZA
CLIFFORD V. HARDING
Research24 Nov 1962
Nature

Volume: 196, P: 786-787
Semipermeability of the Nuclear Membrane

CLIFFORD V. HARDING
CARL FELDHERR
Research06 Sept 1958
Nature

Volume: 182, P: 676-677
Oral Melphalan Therapy in Advanced Malignant Disease

Peter Clifford
R A Clift
J H Gillmore
Research01 Sept 1963
British Journal of Cancer

Volume: 17, P: 381-390
Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

Clifford V. Harding
Emil R. Unanue
Research09 Aug 1990
Nature

Volume: 346, P: 574-576
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

MYD88 mediates the signal of bacterial infection. Here, in the context of periodontal infection, the authors show that the MYD88 pathway in osteocytes plays a dominant role in regulating osteolysis.

Tetsuya Yoshimoto
Mizuho Kittaka
Yasuyoshi Ueki
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

Harding and Boom review the ability ofMycobacterium tuberculosis to inhibit major histocompatibility complex class II antigen presentation through prolonged stimulation of Toll-like receptor 2. They suggest that this reflects a general mechanism of negative-feedback regulation that prevents excessive T cell-mediated inflammation and that M. tuberculosishas subverted to avoid host immune recognition.

Clifford V. Harding
W. Henry Boom
Reviews01 Apr 2010
Nature Reviews Microbiology

Volume: 8, P: 296-307
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

Toll-like receptor 2 is activated by triacylated lipoproteins, but structural and functional studies now show that Mycobacterium tuberculosis lipoprotein LprG is a TLR2 agonist even when it is non-acylated. LprG contains a hydrophobic pocket to bind triacylated glycolipids and delivers them to TLR2, perhaps via CD14. In addition, LprG may serve as a glycolipid chaperone in cell wall assembly by Mycobacterium tuberculosis.

Michael G Drage
Han-Chun Tsai
Clifford V Harding
Research08 Aug 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1088-1095
A rapid, automated surface protein profiling of single circulating exosomes in human blood

Golam Kibria
Erika K. Ramos
Huiping Liu
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic properties of cancer cells through the activation of ERK1/2 signaling pathway.

Lechuang Chen
Zhimin Feng
Ge Jin
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

Taylor W. Schmitz
R. Nathan Spreng
Ansgar J. Furst
ResearchOpen Access04 Nov 2016
Nature Communications

Volume: 7, P: 1-13
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes.

Scott Ayton
Noel G. Faux
Ansgar J. Furst
ResearchOpen Access19 May 2015
Nature Communications

Volume: 6, P: 1-9
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury

Nayer Bagheri
Douglas A Pepple
Steven N Emancipator
Research31 Jan 2005
Laboratory Investigation

Volume: 85, P: 354-363
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17

Search

Injury-induced Synthesis of Deoxyribonucleic Acid in the Lens of the Sea Bass

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Disappearance of Tritiated Thymidine and Tritiated Water from the Anterior Chamber of the Rabbit Eye

Semipermeability of the Nuclear Membrane

Oral Melphalan Therapy in Advanced Malignant Disease

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

A rapid, automated surface protein profiling of single circulating exosomes in human blood

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Search

Quick links

Search

Filter By:

Search

Quick links