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Showing 1–3 of 3 results
Advanced filters: Author: Clint Remarcik Clear advanced filters

  • PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.

    • Russell A. Judge
    • Janani Sridar
    • Qi Hao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.

    • Qi Hao
    • Jin-Mi Heo
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12