Nature Search

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling

Santos et al found that the ubiquitin ligase adaptor Fbxo42 is a critical regulator of terminal Unfolded Protein Response signaling through its control of Ataxin-2 granules containing Xbp1 mRNA.

Cristiana C. Santos
Nadine Schweizer
Pedro M. Domingos
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-19
RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling

Toll-like receptor 4 (TLR4) is a key pattern recognition receptor that primarily responds to ligation of bacterial lipopolysaccharide. Here the authors suggest the intramembrane protease RHBDL4 as a regulator of TLR4 signaling.

Julia D. Knopf
Susanne S. Steigleder
Marius K. Lemberg
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Defying death: showing Bcl-2 the way home

Bcl-2 and Bcl-x_L perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-x_L-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-x_L to the correct cellular locations.

Colin Adrain
Emma M. Creagh
Seamus J. Martin
News & Views01 Jan 2003
Nature Cell Biology

Volume: 5, P: 9-11
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

The conservation and prevalence of inactive homologues in most enzyme families suggests that they may have significant functions that have been largely overlooked. Mechanistic understanding and evolutionary lessons are now emerging from the study of a broad range of such 'dead' enzymes including the recently discovered iRhoms.

Colin Adrain
Matthew Freeman
Reviews11 Jul 2012
Nature Reviews Molecular Cell Biology

Volume: 13, P: 489-498
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

Nicholas Johnson
Jana Březinová
Kvido Strisovsky
ResearchOpen Access04 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Lina Wunderle
Julia D. Knopf
Marius K. Lemberg
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-15
Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery

Tiago Clemente
Narcisio J Vieira
Gustavo P Amarante-Mendes
ResearchOpen Access07 Dec 2017
Cell Death & Disease

Volume: 8, P: e3176

Search

Filter By:

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling

RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling

Defying death: showing Bcl-2 the way home

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery

Search

Quick links