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Showing 1–10 of 10 results
Advanced filters: Author: Colin W. Pouton Clear advanced filters

  • Embryonic stem cells (ESCs) can be used as a source of cellular models for a wide range of adult differentiated cells, providing that reliable differentiation protocols are established. Here, Pouton and Haynes discuss challenges and opportunities regarding the use of ESC-derived models for drug discovery.

    • Colin W. Pouton
    • John M. Haynes
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 605-616

  • Our understanding of cytosolic delivery is hindered by existing methods for quantification which suffer from being indirect and showing low sensitivity. Here the authors report a SLEEQ (Split Luciferase Endosomal Escape Quantification) assay to assess cytosolic delivery of cell-penetrating peptides.

    • Serena L. Y. Teo
    • Joshua J. Rennick
    • Colin W. Pouton
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Resting T cells are difficult to manipulate, and are a reservoir for latent HIV. Here, the authors develop a lipid nanoparticle formulation with the ability to transfect resting primary human T cells, enabling delivery of mRNAs that result in reactivation of latent HIV. This could help development of HIV cure strategies.

    • Paula M. Cevaal
    • Stanislav Kan
    • Michael Roche
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.

    • Alexandra Grubman
    • Xin Yi Choo
    • Jose M. Polo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • Measuring sub-cellular pH with high accuracy and spatiotemporal resolution remains challenging. Here, Johnston and co-workers develop a pH biosensor that combines the pH dependant fluorescent lifetime of mApple with deep learning to accurately determine sub-cellular pH in individual vesicles.

    • Joshua J. Rennick
    • Cameron J. Nowell
    • Angus P. R. Johnston
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • A human embryonic stem cell line expressing a fluorescent reporter of cardiac differentiation is described. The authors use this tool to optimize differentiation methods and to identify cell-surface markers in the cardiac lineage.

    • David A Elliott
    • Stefan R Braam
    • Edouard G Stanley
    Research
    Nature Methods
    Volume: 8, P: 1037-1040

  • Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis.

    • Caroline P. Le
    • Cameron J. Nowell
    • Erica K. Sloan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14