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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Here, a new type of innate effector leukocyte cell — the nuocyte — is described and characterized. It is shown that interleukin (IL)25 and IL33 drive the expansion of the nuocyte population, that these cells secrete IL13, and that they are required for protection against helminth infection.

Daniel R. Neill
See Heng Wong
Andrew N. J. McKenzie
Research01 Apr 2010
Nature

Volume: 464, P: 1367-1370
Noninsulin glucose-lowering agents for the treatment of patients on dialysis

Many noninsulin glucose-lowering agents have pharmokinetic and elimination profiles that preclude their use in patients with reduced renal function. However, several of these drugs can be used safely in patients on dialysis and should be considered by physicians. In this Review, the authors provide a guide to the use of noninsulin hypoglycaemic agents for the management of diabetes in patients receiving dialysis and also discuss the monitoring of glycaemic control in these patients.

Colleen Flynn
George L. Bakris
Reviews29 Jan 2013
Nature Reviews Nephrology

Volume: 9, P: 147-153
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide variety of cationic cargo in numerous cell types.

Brian C. Evans
R. Brock Fletcher
Craig L. Duvall
ResearchOpen Access01 Nov 2019
Nature Communications

Volume: 10, P: 1-19
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Modulation of the unfolded protein response by targeting IRE1 has several potential therapeutic applications. Here, the authors provide a first structural view of inhibitors engaging the RNase-active site of IRE1 that suggests avenues towards the generation of analogues with increased potency and selectivity.

Mario Sanches
Nicole M. Duffy
Frank Sicheri
Research28 Aug 2014
Nature Communications

Volume: 5, P: 1-16
Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation

Joyce Cheung-Flynn
Jun Song
C. Robb Flynn
ResearchOpen Access27 Oct 2017
Scientific Reports

Volume: 7, P: 1-16
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Site-specific hyperphosphorylations of tau in the cerebrospinal fluid change with disease course, and correlate with pathology and cognitive decline in dominantly inherited Alzheimer’s disease.

Nicolas R. Barthélemy
Yan Li
Xiong Xu
Research11 Mar 2020
Nature Medicine

Volume: 26, P: 398-407
Dominance of sulfur-fueled iron oxide reduction in low-sulfate freshwater sediments

Colleen M Hansel
Chris J Lentini
Philip M Jardine
Research14 Apr 2015
The ISME Journal

Volume: 9, P: 2400-2412
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Redox potential as a master variable controlling pathways of metal reduction by Geobacter sulfurreducens

Caleb E Levar
Colleen L Hoffman
Daniel R Bond
ResearchOpen Access03 Jan 2017
The ISME Journal

Volume: 11, P: 741-752
Computational evaluation of exome sequence data using human and model organism phenotypes improves diagnostic efficiency

William P. Bone
Nicole L. Washington
Damian Smedley
ResearchOpen Access12 Nov 2015
Genetics in Medicine

Volume: 18, P: 608-617
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Noninsulin glucose-lowering agents for the treatment of patients on dialysis

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Dominance of sulfur-fueled iron oxide reduction in low-sulfate freshwater sediments

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Redox potential as a master variable controlling pathways of metal reduction by Geobacter sulfurreducens

Computational evaluation of exome sequence data using human and model organism phenotypes improves diagnostic efficiency

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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