The authors examined late- and early-onset murine retinoblastoma tumors and noted that aggressive tumors uniquely expressed an immune gene expression signature. This led to accumulation of a variety of immune cells, including T-lymphocytes, that was not observed in less aggressive tumors. Gene expression analysis identified the immune signature in human and other murine tumors, and they observed it correlated with less proliferative tumors.
- Aaron L. Sarver
- Chencheng Xie
- Timothy C. Hallstrom
