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Showing 1–8 of 8 results
Advanced filters: Author: Colleen S. Kraft Clear advanced filters

  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712

  • Preterm birth (PTB) has high prevalence and PTB infants have greater risk for mortality. Here, Hong and colleagues perform a genome-wide gene × environment interaction analysis and find that maternalCOL24A1variants have a significant interaction with maternal pre-pregnancy obesity in increasing PTB risk.

    • Xiumei Hong
    • Ke Hao
    • Xiaobin Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Humans are exposed to many xenobiotic chemicals, but identification of low abundance xenobiotic exposures is limited by a lack of authentic standards for xenobiotic metabolites. Here the authors develop methods for enzymatic generation of diverse xenobiotic metabolites for use with high-resolution mass spectrometry for biology-based chemical identification.

    • Ken H. Liu
    • Choon M. Lee
    • Dean P. Jones
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.

    • Jens H. Kuhn
    • Takuya Adachi
    • Zabulon Yoti
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 17, P: 261-263

  • Ebola virus disease (EVD) is caused by the filovirus Ebola virus (EBOV). Although the natural host of EBOV is undefined, a single zoonotic transmission is the probable start of most EVD outbreaks. EVD is characterized by gastrointestinal manifestations and multiple organ dysfunction syndrome and has a high case–fatality rate.

    • Shevin T. Jacob
    • Ian Crozier
    • Jens H. Kuhn
    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1-31