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Showing 1–3 of 3 results
Advanced filters: Author: Conor G Loftus Clear advanced filters

  • This article considers the case of a 72-year-old male who presented with epigastric pain, anorexia and progressive jaundice. Liver function tests revealed enzyme abnormalities consistent with cholestasis, while radiographic and endoscopic findings were suggestive of autoimmune pancreatitis with biliary involvement. Examinations for the presence of malignant cells were negative. A diagnosis of autoimmune pancreatitis with IgG4-associated cholangitis was made and the patient was treated with corticosteroids.

    • Aaron J Small
    • Conor G Loftus
    • Todd H Baron
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 5, P: 707-712

  • Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.

    • Róisín M. Loftus
    • Nadine Assmann
    • David K. Finlay
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The molecular dynamics associated with neuronal activation patterns in vivo are unclear. Lacar et al. perform single-nuclei RNA-sequencing of hippocampal neurons from mice exposed to a novel environment, and identify large-scale transcriptome changes in individual neurons associated with the experience.

    • Benjamin Lacar
    • Sara B. Linker
    • Fred H. Gage
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13