Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Constant A. A. van Boeckel Clear advanced filters

  • Computer modelling of the antithrombin III–heparin–thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activites can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.

    • Peter D.J. Grootenhuis
    • Pieter Westerduin
    • Constant A.A. van Boeckel
    Correspondence
    Nature Structural Biology
    Volume: 2, P: 736-739

  • Global antibiotic scarcity looms owing to bacterial resistance. Now the discovery of a class of allosteric inhibitors targeting DNA gyrase—essential for bacteria—yields a compound LEI-800 that exhibits activity against fluoroquinolone-resistant E. coli. The compound’s unique mode of action, revealed through cryo-EM, makes it a promising candidate for countering bacterial resistance.

    • Alexander T. Bakker
    • Ioli Kotsogianni
    • Mario van der Stelt
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1462-1472

  • Chemotherapy-induced peripheral neuropathy (CIPN) represents a major reason for discontinuation of treatment. Here, the authors show that LEI-515, a peripherally restricted monoacylglycerol lipase inhibitor, suppresses CIPN without inducing central nervous system side effects or physical dependence.

    • Ming Jiang
    • Mirjam C. W. Huizenga
    • Mario van der Stelt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • An inhibitor of NAPE-PLD involved in lipid biosynthesis lowers levels of the endocannabinoid anandamide and other N-acylethanolamines in cells and mouse brain and activates the hypothalamus–pituitary–adrenal axis and impaired fear extinction.

    • Elliot D. Mock
    • Mohammed Mustafa
    • Mario van der Stelt
    Research
    Nature Chemical Biology
    Volume: 16, P: 667-675