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Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Saur and colleagues perform a high-throughput combinatorial drug screen and identify a synergistic combination between nintedanib and trametinib that sensitizes mesenchymal PDAC to immune checkpoint blockade.

Chiara Falcomatà
Stefanie Bärthel
Dieter Saur
Research31 Jan 2022
Nature Cancer

Volume: 3, P: 318-336
Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport

Eszter Levai
Iva Marinovic
Claus Peter Schmitt
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-12

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Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport

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