DNA damage arrests the cell cycle in G1. Mlynarczyk et al.show that endoplasmic reticulum stress impairs DNA damage-induced p21 expression in favour of 14-3-3s-mediated G2 arrest by activating the p53 isoform p53/47, resulting in increased apoptosis in cells exposed to both stressors.
- Coraline Mlynarczyk
- Robin Fåhraeus
